A rare case of autoimmune hepatitis overlapping with autoimmune haemolytic anaemia and immune thrombocytopenic purpura in a male patient.

Multiple autoimmune syndrome in a patient with pemphigus vulgaris: a new combination.

BACKGROUND The occurrence in the same patient of three or more autoimmune diseases defines multiple autoimmune syndrome (MAS). Various autoimmune dermatoses, especially pemphigus, have been described in association with systemic autoimmune diseases as component of MAS. AIM The aim of our study is to describe MAS with a new combination in a 55-year-old woman having a pemphigus vulgaris, associ...

Thrombocytopenic purpura in patient with autoimmune haemolytic anaemia, successfully treated with mercaptopurine.

[The effectiveness of rituximab in refractory autoimmune thrombocytopenic purpura and haemolytic anaemia].

OBJECTIVE To evaluate the efficacy and safety of treatment with rituximab in patients presenting autoimmune thrombocytopenic purpura and haemolytic anaemia. METHOD A check was carried out of the medical records of the patients starting treatment with rituximab for compassionate use in 2004 at doses of 375 mg/m2 per week for 4 weeks. The rate of patients achieving full response in accordance w...

Thrombotic thrombocytopenic purpura associated with anti-glomerular basement membrane disease.

Goodpasture's disease is associated with circulating anti-glomerular basement membrane (anti-GBM) antibodies. Thrombotic thrombocytopenic purpura (TTP) is a disease related to platelet clumping and microthrombosis in the circulation. We report an unusual case where both entities coexist in the same patient. The patient was a 43-year-old Caucasian male, with a recent history of inhalational hydr...

Successful Treatment of Refractory Thrombotic Thrombocytopenic Purpura with Rituximab, a Monoclonal Antibody: a Case Report

Thrombotic thrombocytopenic purpura (TTP) is mostly attributed to the presence of an autoantibody against ADAMTS-13, a metalloprotease that degrades ultralarge von Willebrand protein multimers. Accumulation of vWF multimers and systemic platelet aggregation lead to microangiopathic thrombosis, hemolytic anemia, and end-organ ischemia. Most patients respond to therapeutic plasma exchange (TPE), ...